Translational Chemistry for Biomedicine
Developing new analytical technologies to combat disease
and promote wellness & health
Featured Publications
Active-reset protein sensors enable continuous in vivo monitoring of inflammation
H. Zargartalebi, S. Mirzaie, A. Ghavamin-Ejad, S.U. Ahmed, F. Esmaeili, A. Geraili, C.D. Flynn, D. Chang, J. Das, A. Abdrabou, E.H. Sargent, S. O. Kelley
Science, 2024, 386, 6726, 1146-1153.
“A High-Dimensional Microfluidic Approach for Selection of Aptamers with Programmable Binding Affinities.”
D. Chang, Z. Wang, C. Flynn, A. Mahmud, M. Labib, H. Wang, A. Geraili, X. Li, J. Zhang, E. Sargent, S.O. Kelley
Nature Chemistry, 2023, 15, 773-780.
“Isolation of Tumour-Reactive Lymphocytes from Peripheral Blood via Microfluidic Immunomagnetic Cell Sorting.”
Z. Wang, S.U. Ahmed, M. Labib, H. Wang, L. Wu, F. Bavaghar-Zaeimi, N. Shokri, S. Blanco, S. Karim, K. Czarnecka-Kujawa, E.H. Sargent, A.J. McGray, M. de Perrot, S.O. Kelley
Nature Biomedical Engineering, 2023, 7, 1188-1203.
“Efficient Recovery of Potent Tumor-Infiltrating Lymphocytes Through Quantitative Immunomagnetic Cell Sorting.”
Z. Wang, S. Ahmed, M. Labib, H. Wang, X. Hu, J. Wei, Y. Yao, J. Moffat, E.H. Sargent, S.O. Kelley.
Nature Biomedical Engineering, 2022, 6, 108-117.
“Reagentless Biomolecular Analysis Using a Nanoscale Molecular Pendulum.”
J. Das, S. Gomis, J.B. Chen, H. Yousefi, S.Ahmed, A. Mahmud, W. Zhou, E. H. Sargent, S.O. Kelley
Nature Chemistry, 2021, 14, 428-434.
News & Press
- December 2024: Hossein Zargartalebi’s paper “Active-reset protein sensors enable continuous in vivo monitoring of inflammation” was published in Science
- August 2024: Piriththiv Dhavarasa’s paper “Mitochondrial Probe for Glutathione Depletion Reveals NME3 Essentiality for Mitochondrial Redox Response” was published in ACS Chemical Biology
- July 2024: Fatemeh Esmaeili’s paper “Spiky Gold Nanoparticles, a Nanoscale Approach to Enhanced Ex Vivo T-Cell Activation”
- July 2024: Connor Flynn’s paper “Self-Assembled Monolayer Transporters Enable Reagentless Analysis of Small Molecule Analytes” was published in ACS Sensors
- December 2023: Shana is elected to the National Academy of Inventors
- October 2023: Shana spoke at TEDxChicago
- September 2023: Kangfu Chen’s paper “A Magneto-Activated Nanoscale Cytometry Platform for Molecular Profiling of Small Extracellular Vesicles” was published in Nature Communications
- June 2023: Kimberly Riordan was named a Ryan Fellow
- June 2023: Dingran Chang’s paper “A High-Dimensional Microfluidic Approach for Selection of Aptamers with Programmable Binding Affinities” was published in Nature Chemistry
- May 2023: Connor Flynn’s paper “Biomolecular Sensors for Advanced Physiological Monitoring” was published in Nature Reviews Bioengineering
- May 2023: Randy Atwal is a recipient of a Moderna Global Fellowship
- May 2023: Hanie Yousefi is named a 2023 PMSE Future Faculty Awardee
- April 2023: Shana is elected to American Academy of Arts and Science.
- April 2023: Daniel Wang’s paper “Isolation of Tumour-Reactive Lymphocytes from Peripheral Blood via Microfluidic Immunomagnetic Cell Sorting” was published in Nature Biomedical Engineering.
- April 2023: Alam Mahmud’s paper “Monitoring Cardiac Biomarkers with Aptamer-Based Molecular Pendulum Sensors” was published in Angew Chem Int Ed Engl.
Our Research
The projects underway involve aspects of diverse disciplines ranging from materials chemistry to chemical biology and nanotechnology.
Biomolecular Sensors
Advances in genomic and proteomic methods now allow classification of disease based on molecular profiling.
Rare/Single Cell Analysis
We are developing new technology platforms that allow single cell level information to be collected on billions of cells with a high level of throughput. We have applied our approaches to cell profiling to the development of assays for liquid biopsy, disease screening, cell therapy development and therapeutic target discovery.
Intracellular Molecular Delivery
Controlling the intracellular localization of synthetic molecules is essential for effective drug development. Nonetheless, rational control over intracellular trafficking of small molecules has remained a challenge. Our work has focused on mitochondrial targeting with a versatile peptide based vector that promotes efficient cellular uptake and strong mitochondrial localization.
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