Translational Chemistry for Biomedicine

Developing new analytical technologies to combat disease
and promote wellness & health

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Diagram displaying biomolecular analysis on a mouse using a molecular pendulum.

“Reagentless Biomolecular Analysis Using a Nanoscale Molecular Pendulum.”

J. Das, S. Gomis, J.B. Chen, H. Yousefi, S.Ahmed, A. Mahmud, W. Zhou, E. H. Sargent, S.O. Kelley
Nature Chemistry, 2021, 14, 428-434.

Recovery of potent lymphocytes through quantitative immunomagnetic cell sorting

“Efficient Recovery of Potent Tumor-Infiltrating Lymphocytes Through Quantitative Immunomagnetic Cell Sorting.”

Z. Wang, S. Ahmed, M. Labib, H. Wang, X. Hu, J. Wei, Y. Yao, J. Moffat, E.H. Sargent, S.O. Kelley.
Nature Biomedical Engineering, 2022, 6, 108-117.

Tracking the expression of therapeutic protein targets in rare cells

“Tracking the Expression of Therapeutic Protein Targets in Rare Cells by Antibody-Mediated Nanoparticle Labelling and Magnetic Sorting.”

M. Labib, Z. Wang, S.U. Ahmed, R.M. Mohamadi, B. Duong, B. Green, E.H. Sargent
Nature Biomedical Engineering, 2021, 5, 41-52.

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Our Research

The projects underway involve aspects of diverse disciplines ranging from materials chemistry to chemical biology and nanotechnology.

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Drawing of biomolecular sensors

Biomolecular Sensors

Advances in genomic and proteomic methods now allow classification of disease based on molecular profiling.

The detection of a molecular analytes and use of this type of information for disease diagnosis requires methods with high sensitivity and specificity. We are developing new analytical methods with these properties that will permit the direct readout of nucleic acid sequences and protein biomarkers.
Drawing of a cell

Rare/Single Cell Analysis

We are developing new technology platforms that allow single cell level information to be collected on billions of cells with a high level of throughput.  We have applied our approaches to cell profiling to the development of assays for liquid biopsy, disease screening, cell therapy development and therapeutic target discovery.


Microscopic view of intracellular molecular delivery

Intracellular Molecular Delivery

Controlling the intracellular localization of synthetic molecules is essential for effective drug development. Nonetheless, rational control over intracellular trafficking of small molecules has remained a challenge.  Our work has focused on mitochondrial targeting with a versatile peptide based vector that promotes efficient cellular uptake and strong mitochondrial localization.

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The projects underway involve aspects of diverse disciplines!