Translational Chemistry for Biomedicine
Developing new analytical technologies to combat disease
and promote wellness & health
“Reagentless Biomolecular Analysis Using a Nanoscale Molecular Pendulum.”
J. Das, S. Gomis, J.B. Chen, H. Yousefi, S.Ahmed, A. Mahmud, W. Zhou, E. H. Sargent, S.O. Kelley
Nature Chemistry, 2021, 14, 428-434.
“Efficient Recovery of Potent Tumor-Infiltrating Lymphocytes Through Quantitative Immunomagnetic Cell Sorting.”
Z. Wang, S. Ahmed, M. Labib, H. Wang, X. Hu, J. Wei, Y. Yao, J. Moffat, E.H. Sargent, S.O. Kelley.
Nature Biomedical Engineering, 2022, 6, 108-117.
“Tracking the Expression of Therapeutic Protein Targets in Rare Cells by Antibody-Mediated Nanoparticle Labelling and Magnetic Sorting.”
M. Labib, Z. Wang, S.U. Ahmed, R.M. Mohamadi, B. Duong, B. Green, E.H. Sargent
Nature Biomedical Engineering, 2021, 5, 41-52.
News & Press
- Sept 2022: Hossein’s paper “Capillary-Assisted Molecular Pendulum Bioanalysis” was published in J. Am. Chem. Soc.
- Sept 2022: Northwestern Medicine highlighted Fan’s Science Advances paper.
- Sept 2022: Fan’s paper “Genome-wide in vivo screen of circulating tumor cells identifies SLIT2 as a regulator of metastasis” has been published in Science Advances.
- May 2022: Daniel’s paper “Nanoparticle Amplification Labeling for High-Performance Magnetic Cell Sorting” has been published in Nano Letters.
- Apr 2022: Shana awarded a Guggenheim Fellowship to further the group’s work on new sensor technologies.
- Mar 2022: Jenise successfully defends her Ph.D. and take a position at Roche.
- Jan 2022: Daniel’s paper “Efficient recovery of potent tumor-infiltrating lymphocytes through quantitative immunomagnetic cell sorting.” was published in Nature Biomedical Engineering.
The projects underway involve aspects of diverse disciplines ranging from materials chemistry to chemical biology and nanotechnology.
Advances in genomic and proteomic methods now allow classification of disease based on molecular profiling.
Rare/Single Cell Analysis
We are developing new technology platforms that allow single cell level information to be collected on billions of cells with a high level of throughput. We have applied our approaches to cell profiling to the development of assays for liquid biopsy, disease screening, cell therapy development and therapeutic target discovery.
Intracellular Molecular Delivery
Controlling the intracellular localization of synthetic molecules is essential for effective drug development. Nonetheless, rational control over intracellular trafficking of small molecules has remained a challenge. Our work has focused on mitochondrial targeting with a versatile peptide based vector that promotes efficient cellular uptake and strong mitochondrial localization.
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