“A High-Dimensional Microfluidic Approach for Selection of Aptamers with Programmable Binding Affinities.”
D. Chang, Z. Wang, C. Flynn, A. Mahmud, M. Labib, H. Wang, A. Geraili, X. Li, J. Zhang, E. Sargent, S.O. Kelley
Nature Chemistry, 2023, 15, 773-780.
“Isolation of Tumour-Reactive Lymphocytes from Peripheral Blood via Microfluidic Immunomagnetic Cell Sorting.”
Z. Wang, S.U. Ahmed, M. Labib, H. Wang, L. Wu, F. Bavaghar-Zaeimi, N. Shokri, S. Blanco, S. Karim, K. Czarnecka-Kujawa, E.H. Sargent, A.J. McGray, M. de Perrot, S.O. Kelley
Nature Biomedical Engineering, 2023, 7, 1188-1203.
“Efficient Recovery of Potent Tumor-Infiltrating Lymphocytes Through Quantitative Immunomagnetic Cell Sorting.”
Z. Wang, S. Ahmed, M. Labib, H. Wang, X. Hu, J. Wei, Y. Yao, J. Moffat, E.H. Sargent, S.O. Kelley.
Nature Biomedical Engineering, 2022, 6, 108-117.
J. Das, S. Gomis, J.B. Chen, H. Yousefi, S.Ahmed, A. Mahmud, W. Zhou, E. H. Sargent, S.O. Kelley
Nature Chemistry, 2021, 14, 428-434.
“Tracking the Expression of Therapeutic Protein Targets in Rare Cells by Antibody-Mediated Nanoparticle Labelling and Magnetic Sorting.”
M. Labib, Z. Wang, S.U. Ahmed, R.M. Mohamadi, B. Duong, B. Green, E.H. Sargent
Nature Biomedical Engineering, 2020, 5, 41-52.
News & Press
- October 2023: Shana spoke at TEDxChicago
- September 2023: Kangfu Chen’s paper “A Magneto-Activated Nanoscale Cytometry Platform for Molecular Profiling of Small Extracellular Vesicles” was published in Nature Communications
- June 2023: Kimberly Riordan was named a Ryan Fellow
- June 2023: Dingran Chang’s paper “A High-Dimensional Microfluidic Approach for Selection of Aptamers with Programmable Binding Affinities” was published in Nature Chemistry
- May 2023: Connor Flynn’s paper “Biomolecular Sensors for Advanced Physiological Monitoring” was published in Nature Reviews Bioengineering
- May 2023: Randy Atwal is a recipient of a Moderna Global Fellowship
- May 2023: Hanie Yousefi is named a 2023 PMSE Future Faculty Awardee
- April 2023: Shana is elected to American Academy of Arts and Science.
- April 2023: Daniel Wang’s paper “Isolation of Tumour-Reactive Lymphocytes from Peripheral Blood via Microfluidic Immunomagnetic Cell Sorting” was published in Nature Biomedical Engineering.
- April 2023: Alam Mahmud’s paper “Monitoring Cardiac Biomarkers with Aptamer-Based Molecular Pendulum Sensors” was published in Angew Chem Int Ed Engl.
- March 2023: Shana is named President of the Chan Zuckerberg Biohub Chicago.
- March 2023: Kimberly Riordan received a NSF Graduate Research Fellowship.
- November 2022: Abdalla’s paper “nuPRISM: Microfluidic Genome-Wide Phenotypic Screening Platform for Cellular Nuclei was published in ACS Cent. Sci.
- Sept 2022: Hossein’s paper “Capillary-Assisted Molecular Pendulum Bioanalysis” was published in J. Am. Chem. Soc.
- Sept 2022: Fan’s paper “Genome-wide in vivo screen of circulating tumor cells identifies SLIT2 as a regulator of metastasis” has been published in Science Advances.
- May 2022: Daniel’s paper “Nanoparticle Amplification Labeling for High-Performance Magnetic Cell Sorting” has been published in Nano Letters.
- Apr 2022: Shana was awarded a Guggenheim Fellowship to further the group’s work on new sensor technologies.
- Jan 2022: Daniel’s paper “Efficient recovery of potent tumor-infiltrating lymphocytes through quantitative immunomagnetic cell sorting.” was published in Nature Biomedical Engineering.
Advances in genomic and proteomic methods now allow classification of disease based on molecular profiling.
We are developing new technology platforms that allow single cell level information to be collected on billions of cells with a high level of throughput. We have applied our approaches to cell profiling to the development of assays for liquid biopsy, disease screening, cell therapy development and therapeutic target discovery.
Controlling the intracellular localization of synthetic molecules is essential for effective drug development. Nonetheless, rational control over intracellular trafficking of small molecules has remained a challenge. Our work has focused on mitochondrial targeting with a versatile peptide based vector that promotes efficient cellular uptake and strong mitochondrial localization.